What is the maximum dose of mepivacaine for a 70 kg adult?

• A. 300 Mg
• B. 200 Mg
• C. 250 Mg
• D. 350 Mg

Answer: (A)

The main idea is to dose local anesthetics by weight and keep within a safe ceiling to prevent systemic toxicity. For mepivacaine, the commonly cited maximum without a vasoconstrictor is about 4 mg per kilogram. For a 70 kg adult, that calculation gives 280 mg. In many dental pharmacology references this is rounded to a practical cap of 300 mg per dose. That makes 300 mg the best choice because it reflects the usual upper limit used to stay safely under the toxicity threshold. Doses like 200 or 250 mg stay well below the ceiling, while 350 mg would exceed the typical maximum and raise toxicity risk. If a vasoconstrictor were used, the per-kilogram limit can be higher, but the standard exam context for a single-dose maximum often uses the nonvasoconstrictor ceiling of around 300 mg.