What is the interaction between NSAIDs and anticoagulants?

• A. They can decrease bleeding risk and GI irritation.
• B. They have no interaction with anticoagulants.
• C. They can increase bleeding risk and cause GI irritation; use with caution and monitor.
• D. They cure GI irritation.

Answer: (C)

When a patient is on an anticoagulant, adding an NSAID raises the risk of bleeding and can irritate the stomach. NSAIDs inhibit platelet function and damage the gastric lining, while anticoagulants disrupt the clotting cascade. Together, these effects amplify the chance of GI bleeding and easy bruising or prolonged bleeding from minor injuries. That’s why this combination should be used with caution and closely monitored. If pain control is needed, acetaminophen is often preferred; if an NSAID is necessary, use the lowest effective dose for the shortest duration, assess GI risk, consider protective strategies (like a PPI if appropriate), and watch for signs of bleeding such as black stools, vomiting blood, or unusual, prolonged bleeding.