What is a common adverse effect of doxycycline beyond photosensitivity?

• A. Kidney toxicity
• B. Gastrointestinal upset and esophageal irritation if not taken with water
• C. Hair loss
• D. Hypertension

Answer: (B)

Doxycycline commonly causes gastrointestinal irritation, including nausea and stomach upset, and it can irritate the esophagus if the pill isn’t taken with a full glass of water or if you lie down soon after swallowing. Taking it with plenty of water and remaining upright for 30 to 60 minutes helps prevent this esophageal irritation. While photosensitivity is a known concern with doxycycline, GI upset with potential esophageal irritation is a frequent, practical adverse effect clinicians address. Other potential adverse effects like kidney toxicity, hair loss, or hypertension are not typical for doxycycline, making GI upset with esophageal irritation the best choice.